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  1. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis - Hiroyuki Inuzuka, Wenyi Wei - Google книги
  2. The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers
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The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. Conclusions and Research Perspectives. Wei is an expert in the mE3 ubiquitin ligase complexes.

He has published 47 scientific papers, which have received over 2, citations. Gieffers, C. Three-dimensional structure of the anaphase-promoting complex. Cell 7, — Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Gildea, J. PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. Oncogene 23, — Glaser, K. Glotzer, M. Cyclin is degraded by the ubiquitin pathway.

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis - Hiroyuki Inuzuka, Wenyi Wei - Google книги

Gmachl, M. Gray, I. Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN. Cancer 78, — Gray, P. Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer. Cancer Ther. Gu, J. Guardavaccaro, D. Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

Cell 4, — Gutierrez, G. Interplay between Cdh1 and JNK activity during the cell cycle. Hansen, D. Cell 15, — Harmey, D. The anaphase promoting complex induces substrate degradation during neuronal differentiation. Havrda, M. Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. Hayes, M. Hayward, D. The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer. Hollander, M.

PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Cancer 11, — Hsu, J. Huang, H. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.


Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 16, — Hutchins, J. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science , — Inoue, T. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Irniger, S.

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. Jackson, P. Developmental neurobiology: a destructive switch for neurons. Ji, M. Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins. Ji, P. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.

Cell 16, 47— Jiang, L. Brain Res. Johnstone, R.

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Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 4, 13— Jung, S. Id proteins facilitate self-renewal and proliferation of neural stem cells.

Neuronal E3 Ubiquitin Ligase Pam in TSC/MTORC1 Signaling and Synapse Development

Stem Cells Dev. Justilien, V. Oncogene 28, — Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

Kawakami, M. Enhanced expression of prostate-specific membrane antigen gene in prostate cancer as revealed by in situ hybridization. Kawamoto, H. A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model. Ke, P. Genes Dev. Kim, H. Cancer Cell 20, — Kim, S. Cell Dev. Kimata, Y. Kitajima, S. Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. Knecht, R. Prognostic significance of polo-like kinase PLK expression in squamous cell carcinomas of the head and neck.


The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers

Koga, H. Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells. Hepatology 37, — Kops, G. Kotani, S. PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression. Cell 1, — Koul, D. Kouzarides, T. Histone acetylases and deacetylases in cell proliferation. Kowanetz, M.

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Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Kuo, M. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20, — Kwon, C. Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

Lagger, G. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. Lane, H. Antibody microinjection reveals an essential role for human polo-like kinase 1 Plk1 in the functional maturation of mitotic centrosomes. Lasorella, A. Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma.

The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Lee, J. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, — Lehman, N.